The polysaccharides found in seaweed are known for their exceptional potency and diverse composition. In this blog, I would like to introduce the research from a study, “Investigation of effects of fucoidan polysaccharides extracted from two species of Padina on the wound-healing process in the rat” by Moazameh Kordjazj et al. The purpose of this study is to determine the potential of fucoidan polysaccharides for their wound-healing properties.
First, fucoidan from two species of Spadina, P. tetrachromatic and P. boergesenii, were extracted and analyzed using high-performance anion exchange. A total of 40 male rats, under sterile conditions, were assigned to 4 groups and subjected to the performance of two identical paravertebral full-thickness skin wounds, either by burn or excision, while they were anesthetized. Either fucoidan ointment or vehicle (ointment base) was applied to rats’ wounds twice a day for 14 days.
The Fucoidan derived from both types of seaweeds demonstrated a noteworthy decrease in wound area when compared to the control group over multiple time intervals following treatment. The wound area experienced a noticeable decrease at various time points (ranging from day 3 to day 14) when treated with both algal fucoidan, as indicated in Figure 1. Microscopic findings also revealed an improvement in the wound healing process by both algal Fucoidans. This includes a shortened angiogenic phase, early proliferation of fibroblasts, and increased formation of hair follicles and epidermis. (See Figure 2)
In the study, P. boergesenii extracted fucoidan showed significant wound area reduction improvement (better than P. tetrastromatica), especially in the excision model (P < 0.05). (See Figure. 1) The exact mechanism behind this contraction is not completely understood, but there appears to be a complex interaction between contractile fibroblasts called myofibroblasts and matrix components that may be involved. The benefits of contractile changes in excisional wounds outweigh those in burn wounds, primarily because of histopathological differences. This fact is further corroborated by the findings in Figures 1 and 2, which highlight the role of P. boergesenii. The sulfate content of the P. boergesenii extracted polysaccharide was found to be significantly higher (32.6±1%) than that of Tetrastromatica (19±1%), indicating a notable difference between the two. The presence of higher levels of sulfate may contribute to enhanced wound healing properties.
The purified fucoidan interacts with nearby cells by stimulating the synthesis of growth factors and maintaining the stability of heparin activity. Fucoidan binds to several growth factors such as HGF, FGF, etc. Angiogenesis, which occurs during the wound-healing process, contributes secondarily to the secretion of vital growth factors. For example, vascular endothelial growth factor, basic fibroblast growth factor, and TGF-β. In vivo, basic fibroblast growth factor (FGF-2), which is a widely recognized cytokine known for its ability to stimulate fibroblasts and vascular endothelial cells, can induce angiogenesis.
Consistent with this hypothesis, in the present study, we observed a decrease in the extent of vascular beds in pathological tissue samples obtained from resected and burned animals treated with both algal fucoidans. The observation of an improvement in epithelialization was made with the use of both algal fucoidans. Successful re-epithelialization of excisional wounds depends on a combination of factors, including efficient proliferation and migration of epidermal progenitor cells from the injured skin and hair follicle edges.
Both algal fucoidans have the potential to stimulate the epithelium, primarily by facilitating fibroblast migration to the wound area and generating paracrine effects.
The study provided evidence that fucoidan, which was extracted from two types of brown algae (P. boergesenii and P. tetrachromatic) found in the Persian Gulf, is abundant in sulfate and possesses therapeutic qualities. This is the first time that the healing properties of fucoidan have been demonstrated in full-thickness burn and excisional wound models in rats. Topical ointments made with P. borgesseni fucoidan appear to be more effective than P. tetrachroic fucoidan, especially in cases of excision.
There may be a correlation between the wound healing model and a higher sulfate content.
Source: Turk J Vet Anim Sci (2017) 41: 106-117© TÜBİTAK doi:10.3906/vet-1603-21
You are a very persuasive writer. I can see this in your article. You have a way of writing compelling information that sparks much interest.
I appreciate your comment. I hope my blog help to keep your health well.
Some times its a pain in the ass to read what people wrote but this web site is very user friendly ! .
Thank you for your valuable comment.
The article posted was very informative and useful. You people are doing a great job. Keep going.
I appreciate your encouraging comments
Your blog is a true masterpiece – thank you!Could you please assist me in receiving the confirmation email for my subscription?
I appreciate your comment and asking how to subscribe, but my blog is personal, so I am sorry that I have the system to let you subscribe my blog.
Your blog is a true gem – thanks for your hard work!I’m ready to subscribe, but I’m experiencing a delay in the confirmation email.
I appreciate your comment and asking how to subscribe, but my blog is personal, so I am sorry that I have the system to let you subscribe my blog.
I am really loving the theme/design of your web site. Do you ever run into any browser compatibility problems? A few of my blog readers have complained about my website not working correctly in Explorer but looks great in Chrome. Do you have any tips to help fix this issue?
I am sorry that my blog is personal, so I do not have any system to help you, but I am very much appreciate your comment.
Absolutely pent subject matter, appreciate it for selective information .
Thank you for your valuable comment. I hope my blog help you improve your health.
This is such a great post, and was thinking much the same myself. Another great update.
Thank you very much for your comment. Your comment make me work harder to help to improve healthy lives.
Your blog is a must-read for anyone in the industry – thank you!Is there a way to re-trigger the confirmation email for my newsletter subscription?
I am sorry that my blog is personal, so I do not have any system to help you, but I am very much appreciate your comment.
Your blog is a true testament to your expertise – thank you!Can you check on the status of my newsletter subscription confirmation email?
I am sorry that my blog is personal, so I do not have any system to help you, but I am very much appreciate your comment.
Appreciate the effort you put into making your blog exceptional.I haven’t received the confirmation email after signing up for the newsletter.
I am sorry that my blog is personal, so I do not have any system to help you, but I am very much appreciate your comment.
Many thanks for sharing your expertise through your blog.Can you help me troubleshoot why I haven’t received the confirmation for my subscription?
I am sorry that my blog is personal, so I do not have any system to help you, but I am very much appreciate your comment.
Thanks for being a reliable source of information and inspiration.I’ve encountered a delay in receiving the confirmation email for my newsletter subscription.
I am sorry that my blog is personal, so I do not have any system to help you, but I am very much appreciate your comment.
Your blog is a testament to your expertise – thank you!I’ve submitted my email for subscription but haven’t received the confirmation email.
I appreciate your comment, but my blog is private, so I do not have the system of subscription. Your comment makes me encouragement to provide more accurate information, Thank you again.
I appreciate the depth and breadth of your blog content.I’m looking forward to your newsletter but haven’t received the confirmation email yet.
I appreciate your comment, but my blog is private, so I do not have the system of subscription. Your comment makes me encouragement to provide more accurate information, Thank you again.
I’m thankful for the value your blog adds to my life.Excited to be a part of your newsletter, but the confirmation email hasn’t arrived.
I appreciate your comment, but my blog is private, so I do not have the system of subscription. Your comment makes me encouragement to provide more accurate information, Thank you again.
Thanks for making your expertise accessible through your blog.I’ve entered my email for subscription, but the confirmation email hasn’t arrived.
I appreciate your comment, but my blog is private, so I do not have the system of subscription. Your comment makes me encouragement to provide more accurate information, Thank you again.
Your blog has been an invaluable resource – thank you!I’m looking forward to subscribing, but I haven’t received the confirmation yet.
I appreciate your comment, but my blog is private, so I do not have the system of subscription. Your comment makes me encouragement to provide more accurate information, Thank you again.