Oligo-Fucoidan extracted from Laminaria japonica is a sulfated polysaccharide with various biological and beneficial influences, such as anti-inflammatory and antitumor effects, and has also been shown to have beneficial health impacts. The molecular mechanisms underlying the therapeutic effects of oligo-fucoidans in cancer patients remain unclear. Therefore, in this blog, I would like to share the […]
Category: Fucoidan
The human body has striated muscles and smooth muscles. For example, the muscles of the limbs and heart related to movement are striated (attached to the skeleton), and the muscles of the stomach, esophagus, and internal organs are smooth (observed in internal organs). Hence, a benign tumor that is developed in the smooth muscle is […]
Obesity, including excessive body fat accumulation, is closely associated with the development of cardiovascular disease, insulin resistance (IR), Type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Hypertrophic adipocytes also secrete adipokines such as adiponectin, leptin, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), which are known to alter insulin activity in adipose tissue, liver, and […]
In this article, I would like to share how fucoidan prevents M2 macrophage differentiation and also discuss how fucoidan differentiates M2 through a study. Macrophage infiltration within and around the tumor nest is one of the essential hallmarks during tumor progression. According to Jiuyang Liu et al., “New insights into M1/M2 macrophages: key modulators in […]
The pathogenesis of ALD (Alcohol Liver Disease) is known to be complicated. Additionally, the occurrence of lipid metabolism disorders, oxidative stress, and inflammatory reactions have been confirmed in the studies. Alcohol-induced cytochrome P450-2E1 (CYP2E) can oxidize excess amounts of ethanol to acetaldehyde and generate large amounts of reactive oxygen species (ROS), leading to mitochondrial damage […]
Lung cancer morbidity and mortality rates have been increasing each year. It has a 5-year survival rate of only 18% for non-small cell lung cancer (NSCLC), which accounts for 80-85% of lung cancers. Although there are cases in which chemotherapy and molecular-targeted drugs are effective, the side effects are severe. Additionally, only a few people […]
Fucoidan is a type of sulfated polysaccharide contained in brown algae such as mozuku and kelp. Past studies on fucoidan have reported anti-inflammatory, antiviral, and antitumor effects. Furthermore, researchers previously conducted studies on the immunostimulation of fucoidan. They found that the number of immune cells increased, macrophage phagocytosis enhanced, IgM, IgG, and IgA antibody production […]
The biliary tract is a general term for the bile duct, gallbladder, and papilla of the duodenum, which are channels for bile. Hence, malignant tumors occurring in these areas are called biliary tract cancer. Additionally, Cholangiocarcinoma is one of the advanced cancer types that appears as a symptom after it blocks the bile duct and […]
Metastasis is known to be the leading cause of cancer-related death. Cancer cells enter blood vessels and lymphatic vessels from where they first formed, travel along the blood and lymph flow to another organ or multiple organs, and multiply there. The most common cases are metastasis to lymph nodes where the flow of lymph fluid […]
Mesenchymal stem cells (MSCs) are a source of cell-based therapeutics, as MSCs have tissue regeneration potential. For example, one of the characteristics of mesenchymal stem cells is that they are introduced into the patient’s body at a stage just before they become the target cells. As a result, they differentiate into the target cells in […]