Hepatocellular carcinoma, which is identified as a primary and significant form of liver cancer, stands out as one of the most fatal types of tumors, primarily attributed to its substantial morbidity rates and generally unfavorable prognosis. On the other hand, Fucoidan has been demonstrated to exhibit a broad spectrum of biological activities, encompassing antioxidant, anti-inflammatory, […]
Among patients diagnosed with chronic kidney disease (CKD), a frequently encountered complication is the presence of mineral and bone disorder (MBD), which is a recognized consequence of this condition. The need for advanced CKD-MBD treatments is therefore highly significant from a clinical standpoint. Fucoidan (FPS), which originates from the Japanese kelp (Laminaria japonica), is a […]
Cisplatin has become a cornerstone in the treatment of numerous types of cancer, serving as a standard and frequently utilized chemotherapeutic agent. On the other hand, severe ototoxicity is a known side effect of cisplatin treatment. On the other hand, fucoidan, a complex sulfated polysaccharide primarily derived from brown algae, exhibits diverse physiological activities, including […]
In this blog, I would like to inform you of the study, “A Fucus vesiculosus(FVE)extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines” by Jianqing Zhang et al, which aimed to evaluate the potentially biologically relevant antitumor effects of the brown alga Fucus vesiculosus in estrogen receptor (ER)-dependent and -independent […]
Undaria pinnatifida fucoidan (UPF), a bioactive sulfated polysaccharide, is widely known to have anti-inflammatory, antioxidant, antitumor, anticoagulant, antiviral, and immunomodulatory properties. The exact mechanism by which UPF regulates inflammation and neuronal health is unclear. In this blog, I would like to inform you of the study,” Neuroprotective and Anti-Inflammatory Activity of Undaria pinnatifida Fucoidan In […]
Cardiac remodeling plays a key role in the advancement of heart disease and commonly causes heart failure. Galectin-3 (Gal-3), a β-galactoside-binding lectin, has emerged as a key mediator of cardiac remodeling. Elevated Gal-3 levels are associated with poor cardiac prognosis, including fibrosis and inflammation, making it a potential therapeutic target. Previous studies have demonstrated that […]
Chronic kidney disease (CKD), a condition characterized by persistent abnormalities in the structure and function of the kidney, can be attributed to a range of different factors. Over the past decade, CKD has become a significant cause of morbidity and mortality worldwide, with a cumulative mortality rate reaching 20.6%. Cognitive problems in individuals with CKD […]
Malignant glioma (MG) is a brain tumor that carries a grim outlook for patients, as the disease is characterized by the unavoidable recurrence of the tumor despite the application of different therapeutic interventions. The discovery of better treatments is essential, and the need for this is critical. On a positive side, Fucoidan, a sulfated polysaccharide […]
There is a substantial correlation between a high-salt diet (HSD) and several medical conditions, such as hypertension, chronic kidney disease, and autoimmune disorders, which are all significantly impacted. However, the mechanisms underlying HSD-induced inflammation and exacerbation of these diseases have not been fully elucidated. This blog will discuss the study, “L-fucose and fucoidan alleviate high-salt […]
Mitochondria are considered the cellular energy source. In dopaminergic neurons of Parkinson’s disease (PD), mitochondria are the organelles most susceptible to damage. Despite the importance of protecting neuromitochondrial function in PD patients, the detailed mechanisms of mitochondrial dysfunction during the pathogenesis and pathophysiological progression of PD remain unclear. In this blog, I would like to […]