Patients with chronic kidney disease (CKD) and impaired kidney function often develop mineral and bone disorders. These include metabolic imbalances in calcium, phosphorus, parathyroid hormone, vitamin D, and FGF23, resulting in abnormal bone structure and vascular calcification. Recently, CKD-mineral and bone disorder (CKD-MBD) has become one of the common complications occurring in CKD patients with […]
Fucoidan, a polysaccharide, comes from marine sources. Fucoidan’s diverse biological activities, including lipid-lowering, anti-atherosclerosis, and anticoagulation, have made it increasingly popular in recent years. In this blog, I would like to introduce the study, “Application of fucoidan as a treatment for cardiovascular and cerebrovascular diseases” by Ke Wang et al. This study reveals how fucoidan […]
Diabetes poses a considerable and growing threat to global human health, as its incidence continues to rise internationally, demanding increased attention to prevention and treatment strategies. Although current medications reduce diabetes mortality and morbidity, their adverse health effects are becoming an urgent issue. In contrast, supplementing with polysaccharides provides an effective, side-effect-free approach to managing […]
The strong correlation between high-salt diets, defined as diets with excessive intakes of salt, and the development of a number of serious illnesses, including hypertension, chronic kidney disease, and various autoimmune diseases, is well established in the medical literature. However, the mechanisms underlying HSD-induced inflammation promotion and exacerbation of these diseases have not been fully […]
Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is a complex, chronic, and multifactorial gastrointestinal disease of unknown origin that is characterized by periods of intestinal inflammation that relapse and remit. Fucoidan, a sulfated polysaccharide derived from brown algae, in contrast, is a recognized anti-inflammatory agent; furthermore, research indicates that fucoidan […]
Fucoidan Protects against Doxorubicin-Induced Cardiotoxicity by Preventing Mitochondrial Dysfunction
Doxorubicin (DOXO), a chemotherapy medication, treats various cancers, including breast cancer, solid tumors, leukemia, and soft tissue sarcoma. However, the therapeutic value and clinical application of DOXO are limited by both acute and chronic life-threatening cardiotoxicity, including arrhythmias, tachycardia, and even severe congestive heart failure and left ventricular dysfunction. Doxorubicin causes cellular atrophy; its induction […]
The anti-aging properties of Sargassum, a brown algae, have been highlighted in recent studies. Sargassum extracts and their derivatives hold great promise in skincare because of their many benefits, including antioxidant, anti-inflammatory, whitening, skin barrier repair, and moisturizing properties. In this blog, I would like to introduce the study, “Potential Beneficial Effects of Sargassum spp. […]
Malignant tumor metastasis, the process by which cancer spreads, is a crucial aspect of the disease and accounts for the vast majority of deaths attributed to cancer. Tumor metastasis via lymphatic vessels is considered one of the fundamental steps in the metastatic dissemination of tumors. The development of effective new cancer treatments thus requires the […]
The inflammatory response to spinal cord injury involves activated immune cells and pro-inflammatory mediators that worsen tissue damage and disrupt normal neuronal activity. SCI induces widespread apoptosis of neurons, further compromising the structural and functional integrity of the spinal cord. This complex interplay of pathological processes poses a major obstacle to effective SCI treatment strategies. […]
In this blog post, I want to draw your attention to the third installment in this series, specifically focusing on the section within Kenneth G. Collins et al.’s work, “Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases,” which details the crucial area of Polysaccharides and Prebiotics. The cell walls […]