The spread of malignant tumors, known as metastasis, is a significant aspect of these tumors and is the primary reason why most cancer patients die. A crucial initial phase in the spread of cancerous tumors is metastasis through lymphatic vessels, which also serves as a predictor of patient outcome. Fucoidan, a naturally occurring sulfated polysaccharide, […]
Sea Cucumber Cucumaria Frondosa Fucoidan Inhibits Osteosarcoma By Regulating Cytoskeleton Remodeling
In children and adolescents around the world, the most common primary malignant bone cancer is osteosarcoma (OS), and a combination of surgery and multiagent chemotherapy has led to a significant improvement in the 5-year cumulative survival rate of primary OS. Despite treatment, roughly 80% of OS patients see pulmonary metastases develop, and this is the […]
The prognosis for individuals dealing with uterine sarcomas and carcinosarcoma is typically unfavorable, highlighting the serious nature of these conditions. However, chemotherapy treatments tend to have many side effects and generally don’t help patients live longer. As a result, this blog will cover the study “Isobolographic Analysis Demonstrates the Additive and Synergistic Effects of Gemcitabine […]
It is well-established that reduced lung function is a characteristic of both infectious and non-infectious pathologies; however, it is crucial to recognize that viral infections affecting the lungs can lead to both immediate and chronic damage that persists over time. For example, SARS-CoV-2 infection suppresses innate immunity and promotes inflammatory responses. Clinical and animal studies […]
Oxidative stress has been suggested to be the main cause of Diabetic cardiomyopathy (DCM) development. This blog informs you of the study,” Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis” by Xinfeng Yu et al, that evaluates the protective effect of low molecular weight fucoidan […]
Mycoplasma pneumoniae, a type of pneumonia, is frequently seen in healthy individuals; however, it is especially common in children and young adults. A long-lasting cough, a typical or slightly increased white blood cell count, the inability of penicillin and cephalosporin antibiotics to be effective, along with a positive result on a cold agglutination test are […]
The subject of this blog is the study by Yan Xu et al., “Fucoidan Improves D-Galactose-Induced Cognitive Dysfunction by Promoting Mitochondrial Biogenesis and Maintaining Gut Microbiome Homeostasis.” The study aimed to explore the protective impact of fucoidan from Saccharina japonica in D-galactose-induced cognitive impairment and its mechanism. Fucoidan, a natural substance that shows potential, is […]
Hypertension affects inflammatory pathological changes in the retina. In this blog, the study, “Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights” by Jing Li et al, that investigate whether sirtuin 1 (SIRT1) controls angiotensin II (Ang II)-induced hypertensive retinopathy and inflammation by regulating the activation of NOD-like receptor […]
Mitochondrial dysfunction is thought to play a key role in dopamine neuron degeneration in patients with sporadic and familial Parkinson’s disease (PD), so approaches aimed at preserving mitochondrial function may hold great promise in the prevention and treatment of PD. In this blog, it presents the study, “Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial […]
The marine-derived polysaccharide fucoidan combines multiple biological activities. Various in vitro and in vivo studies have demonstrated that fucoidan exhibits antiviral, antitumor, antioxidant, anti-inflammatory, and anticoagulant properties. In this blog, I would like to share the study, “Crude Fucoidan Extracts Impair Angiogenesis in Models Relevant for Bone Regeneration and Osteosarcoma via Reduction of VEGF and […]