Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is a complex, chronic, and multifactorial gastrointestinal disease of unknown origin that is characterized by periods of intestinal inflammation that relapse and remit. Fucoidan, a sulfated polysaccharide derived from brown algae, in contrast, is a recognized anti-inflammatory agent; furthermore, research indicates that fucoidan […]
Fucoidan Protects against Doxorubicin-Induced Cardiotoxicity by Preventing Mitochondrial Dysfunction
Doxorubicin (DOXO), a chemotherapy medication, treats various cancers, including breast cancer, solid tumors, leukemia, and soft tissue sarcoma. However, the therapeutic value and clinical application of DOXO are limited by both acute and chronic life-threatening cardiotoxicity, including arrhythmias, tachycardia, and even severe congestive heart failure and left ventricular dysfunction. Doxorubicin causes cellular atrophy; its induction […]
The anti-aging properties of Sargassum, a brown algae, have been highlighted in recent studies. Sargassum extracts and their derivatives hold great promise in skincare because of their many benefits, including antioxidant, anti-inflammatory, whitening, skin barrier repair, and moisturizing properties. In this blog, I would like to introduce the study, “Potential Beneficial Effects of Sargassum spp. […]
Malignant tumor metastasis, the process by which cancer spreads, is a crucial aspect of the disease and accounts for the vast majority of deaths attributed to cancer. Tumor metastasis via lymphatic vessels is considered one of the fundamental steps in the metastatic dissemination of tumors. The development of effective new cancer treatments thus requires the […]
The inflammatory response to spinal cord injury involves activated immune cells and pro-inflammatory mediators that worsen tissue damage and disrupt normal neuronal activity. SCI induces widespread apoptosis of neurons, further compromising the structural and functional integrity of the spinal cord. This complex interplay of pathological processes poses a major obstacle to effective SCI treatment strategies. […]
In this blog post, I want to draw your attention to the third installment in this series, specifically focusing on the section within Kenneth G. Collins et al.’s work, “Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases,” which details the crucial area of Polysaccharides and Prebiotics. The cell walls […]
For this blog, I’d like to specifically point you toward a key section of Kenneth G. Collins et al.’s publication, “Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases”. The details include research and findings related to diabetes and obesity and will serve as the secondary theme of this blog […]
Many studies highlight seaweed’s rich supply of biologically active metabolites with promising therapeutic applications, such as anti-cancer, antioxidant, anti-inflammatory, and anti-diabetic treatments. The West’s adoption of modern lifestyles has resulted in less physical activity and diets high in calories and saturated fat. This has led to an increasing number of reported chronic non-communicable diseases (NCDs), […]
Cytokine and chemokine reprogramming has a direct impact on the functional changes occurring in M1 and M2 macrophages, with CCL22, a chemoattractant, being produced mainly by M2 macrophages activated by the Th2 cytokines IL-4 and IL-13. The chemokine CCL22 is highly expressed in various malignancies, including ovarian tumors, colorectal tumors, breast cancer, hepatocellular carcinoma, and […]
Triple-negative breast cancer (TNBC) affects about 20% of breast cancer patients and is characterized by a high recurrence rate within three years. Sadly, after recurrence, survival rates for TNBC are lower than other breast cancer types. In addition, hormone therapy and the molecular targeted drug Herceptin therapy, which are commonly used in the treatment of […]